Nur77 deficiency leads to systemic inflammation in elderly mice

nuri77Generation of MCK-Nur77 mice and animal husbandry. The murine Nur77 coding sequence was PCR amplified and cloned into the EcoRI site of the pCK4800 plasmid (gift of Eric Olson).TheThe mechanism of Nur77 regulating cell survival and apoptosis in CNS. Nur77 mediates cell apoptosis through caspase, endoplasmic reticulum stress, and mitochondrial autophagy, while